The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine.
نویسندگان
چکیده
HSP90 is an abundant protein in Leishmania parasites that plays a major role in the parasite survival under stress conditions. Here we found that the HSP90 inhibitor 17-AAG (≥100nM 17-AAG) induced cell cycle arrest at G0/G1 in Leishmania infantum and Leishmania panamensis promastigotes, and highly potentiated the induction of cell death by an apoptotic-like process mediated by the ether phospholipid edelfosine (5-20μM). These data suggest that the combined treatment of 17-AAG and edelfosine might be a novel and effective approach of combination therapy in the treatment of leishmaniasis.
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ورودعنوان ژورنال:
- Acta tropica
دوره 131 شماره
صفحات -
تاریخ انتشار 2014